import csv
# Data
headers = ['Header1', 'Header2', 'Header3']
rows = [[1,2,3], [5,6,7]]
# Open a file to append to
with open('/path/target_file.txt', 'a') as f:
    # CSV writer instantiation
    writer = csv.writer(
      f
      # Settings
      , quoting=csv.QUOTE_NONE
      , delimiter='\t'
     )
    # Headers
    writer.writerow(headers)
    # All rows
    writer.writerows(rows)